Aim. To evaluate different parameters in differentiating intestinal BD from CD. Methods. The medical records of inpatients with\nintestinal BD and CD were retrospectively reviewed. The univariate value of different parameters was analyzed, respectively. A\ndifferentiation model was established by pooling all valuable parameters together. Diagnostic efficacy was evaluated, and a\nreceiver operating curve (ROC) was plotted. Results. Forty-two BD patients and ninety-seven CD patients were reviewed.\nDemographic and clinical parameters that showed significant value included diarrhea, fever, perianal disease, oral ulcers, genital\nulcers, skin lesions, and musculoskeletal lesions. Endoscopic parameters reaching clinical significance included multiple-site\nlesions, lesions confined to the ileocecal region, longitudinal ulcers, round or oval ulcers, punch-out ulcers, ulcers with discrete\nmargin, ulcer size > 2 cm, stricture of bowel, and anorectal involvement. Radiologic parameters aiding the differentiation\nincluded involvement segments � 3, asymmetrical pattern of involvement, intraluminal pseudopolyp formation, target sign,\nstricture with proximal dilation, comb sign, and fistula. The sensitivity, specificity, accuracy, positive predictive value, and\nnegative predictive value of the differentiation model were 90.5%, 93.8%, 92.8%, 86.4%, and 95.8%, respectively. The cutoff value\nwas 0.5 while the area under the ROC curve was 0.981. Conclusion. The differentiation model that integrated the various\nparameters together may yield a high diagnostic efficacy in the differential diagnosis between intestinal BD and CD.
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